People use ThumbsPlus to work with TIFF files many times larger than that, so the size should not be a problem.
Ctrl+Enter opens an image in full screen mode. I don't expect it to make a difference, but have you tried just pressing Enter too, for a windowed viewer?
There's an option "Disable TIFF library memory mapping" under Options > File Loading > TIFF that you could try.
When you right-click on a TIFF file and select "Configure Type", what does it say for "Load file using:"? Values that should work are 'internal' and 'polyimage'.
When you use the same scanning software to produce a much smaller (low res) image, does that load? If not, do you see any error messages?
Something else to try:
[*]Go to Help | System Info and see what your 'Preferences path' is.
[*]Exit TP and go to that folder.
[*]Open your settings file, thumbs9.ini, in a text editor (eg. notepad) and add the following section to it:
[Virtualmemory]
Minalloc=0[*]Save the changes and re-launch TP to see if that has solved it.
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And finally..:Have you tried on a different system?
If none of this helps, maybe you can post one of those files on dropbox and send me a link (or post it here) so I can see if it works here. TIFF is a complicated envelope format that can use a plethora of different internal compression and encoding schemes, even proprietary ones, and although it would seem unlikely that Nikon would do so, there is a small chance that this particular flavor just isn't (fully) supported.
